Download Free Medical Acute Angioedema PowerPoint Presentation

Acute Angioedema PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : This medical presentation titled "Acute Angioedema" talks about differential diagnosis of acute angioedema, causes of anaphylaxis, treatment of severe allergic reactions, and differential diagnosis of acute angioedema

Tags : Allergy, Acute Angioedema, histamine, In vitro sIgE-testing, Mechanism, NSAIDs, Treatment

Published on : Apr 24, 2021 | Views : 2905 | Downloads : 5

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Acute Angioedema Gabriele de Vos, M.D., M.Sc. Division of Allergy and Immunology Jacobi Medical Center Albert Einstein College of Medicine
Slide 2-

ppt slide no 2 content not found
Slide 3-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 4-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 5-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Immediate type (histamine) Severe reactions (anaphylaxis) almost always occur within 1-30 min Anaphylaxis is accompanied by skin symptoms in nearly 100% Up to 20% late phase reaction 2-24 hours (peak 8 hours)
Slide 6-

How do mast cells release histamine?
Slide 7-

ppt slide no 7 content not found
Slide 8-

Presentation of anaphylaxis
Slide 9-

Causes of anaphylaxis
Slide 10-

Work-up of IgE mediated allergic reactions Skin-testing Drugs: no standardized skin tests, except penicillin Food: best with fresh food NPV thought to be generally >95% PPV 50%1 – 95% (milk, egg, peanut, if wheal >8mm)2 Refractory period up to 4 weeks after anaphylaxis (data from venom anaphylaxis) 1Kagan et al., Ann Allergy Asthma Immunol. 2003 Jun;90(6):640-5 2003 2Sporik R, Hill DJ et al. Clin Exp Allergy. 2000 Nov;30(11):1540-6.
Slide 11-

Work-up of IgE mediated allergic reactions In vitro sIgE testing “RAST” (RadioAllergoSorbentTest)-outdated test, but term still in use! Newer tests: Radioactive signal replaced by chemiluminescent reaction (DPC Immulite 2000, PharmaciaCap) Limited sensitivity and specificity
Slide 12-

Probability of reacting to egg Sicherer et al. 2005
Slide 13-

Treatment of severe allergic reactions 1. Epinephrine (Adrenaline) 1:1000 solution (=1mg/ml) >12 years and adults: 0.3-0.5 mg IM anterolateral thigh; (IV must dilute: 0.1-0.3 mg (in 10ml) slowly over 10 minutes) >6 months and <12 years: 0.01 mg/kg 2. Positioning: Keep patient lying flat with legs up unless respiratory distress increases 3. Oxygen supplementation and beta-agonist inhalation (Albuterol) 4. IV access, intravenous fluids (normal saline) if still hypotensive after epinephrine Remember: 50% of the intravascular volume can be shifted to the extravascular space within the first 10 min. of anaphylaxis Normal Saline rapid infusion if epinephrine-resistant hypotension 5. If patient is on beta-blocker: Glucagon Adult: 1-5 mg IV (IM,SC), followed by infusion 5-15 ug/min 6. Antihistamines Adult: H1-antagonist (Diphenhydramine=Benadryl® 25-50 mg IV) and H2-antagonist (Famotidine=Pepcid® 20mg IV) Children (2-12y): H1-antagonist (Diphenhydramine=Benadryl®1-1.25 mg/kg IV q6h) and H2-antagonist (Famotidine=Pepcid® 0.25-0.5 mg/kg IV q12h) 7. Steroids: do not help acutely but can prevent prolonged anaphylaxis Liebermann et al. “The diagnosis and management of anaphylaxis. An updated practice parameter”, JACI 2005; 115
Slide 14-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 15-

Differential diagnosis of acute angioedema Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food. Immediate or delayed onset of symptoms Mechanism not well understood Opiates, radio contrast media and vancomycin are typical examples There is increasing data that certain food can trigger histamine release in susceptible individuals (e.g. chronic urticaria) Food that can enhance allergic skin reactions: Any spices and seasoning such as Sazon, Adobo, Vegeta, ginger, garlic, onion or celery powder, any MSG containing food (e.g. Chinese food) etc. Premixed dressings for salads such as 1000 islands, blue cheese, French dressing etc. (Only oil and a touch of vinegar or lemon juice should be used for salad dressing) Canned tomatoes, tomato sauce or paste, canned soups, other canned meals Vinegar and vinegar-containing foods such as mayonnaise, ketchup, and mustard, salad dressings, chili, shrimp sauce, pickles, pickled vegetables, relishes, green olives, and sauerkraut. Beer, wine and cider Mushrooms. Soy sauce. Pickled and smoked meats and fish including sausages, bacon, ham, hot dogs, corned beef, pastrami, and pickled tongue. Lobster and shellfish. Soured breads (e.g. pumpernickel, rye) fresh rolls, coffee cakes Certain fruits such as melons, especially cantaloupe, mango, all tropical fruit (pineapple, papaya etc.), grapes, strawberries All dried and candied fruits including raisins, apricots, dates, prunes, and figs. Diet soda, sodas containing artificial coloring (in particular orange and grape, mountain dew), ginger ale, Snapple, fruit punches of any kind, iced tea, any powdered drinks, health food preparations, any herbal teas (e.g. ginger or lemon or orange spice tea), herbal medicines, vitamins or tonics unless prescribed. Chocolate, nuts, peanut products, chewing gum, breath mints, candy Milk and milk products; Cheeses, in particular aged cheeses, in some cases also cottage cheese, sour cream, and buttermilk
Slide 16-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 17-

Angioedema Mechanism of action of NSAIDs (non selective Cox-inhibitors)
Slide 18-

ACE-inhibitor NOSNO Mechanism of action of ACE inhibitor Angioedema
Slide 19-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 20-

Differential diagnosis of acute angioedema IgE mediated allergic reactions to food, drugs, venoms etc. Histamine-releasing drugs (e.g. opioids, RCM), pseudoallergens in food Adverse reactions to certain medications: NSAIDs, ACE-inhibitors Chronic urticaria with angioedema Idiopathic or exercise induced anaphylaxis C1-Esterase Inhibitor deficiency (hereditary or acquired) Gleich syndrome: recurrent angioedema and high eosinophil counts of unknown etiology Angioedema in hypereosinophilic syndrome
Slide 21-

C1 inhibitor deficiency (hereditary or acquired) Hereditary: au.-dom.,can begin in childhood, ~1:30.000 30% new mutations Depending on gene defect either type I (deficient quantitative production) or type II (deficient qualitative production); type III with nl C1 inh recently described in women, still poorly understood Acquired: over utilization of the normal C1 inhibitor by high levels of antigen-antibody complexes factors formed by lymphoid tumors that destroy C1-INH activity autoantibody to the C1-INH that prevents its function Attacks are typically triggered by trauma (e.g. dental surgery), infection, stress, ACE inhibitors, etc.
Slide 22-

Morgan, NEJM 2010 The role of C1 inhibitor and available treatments
Slide 23-

C1 inhibitor concentrates: Cinryze® (pateurized, nanofiltered C1 inh concentrate approved for prophylaxis of attacks; studies showed 50% reduction in severity and frequency of attackes (50%) if infused twice weekly Attenuated Androgens (danazol, stanazol): increase C1 inh production in liver Antifibrinolytic agents (tranexamic acid, epsilon-aminocaproic acid): inhibit plasminogen activation with consequent “sparing” of C1 inh usage The role of C1 inhibitor and available treatments
Slide 24-

Complement levels in C1 inhibitor deficiency *during attack
Slide 25-

Questions ?
Slide 26-

In vitro sIgE-testing Sampson et al. JACI 2003.111:S542