Download Free Medical 88 Years of Influenza Pandemics in 15 Minutes PowerPoint Presentation

88 Years of Influenza Pandemics in 15 Minutes PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical presentation on Influenza (Flu), which is titled "88 Years of Influenza Pandemics in 15 Minutes", to know about the history and background of pandemic influenza.

Tags : Influenza, Flu, pandemic influenza

Published on : Jul 12, 2021 | Views : 1427 | Downloads : 3

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Bureau of Emergency Preparedness and Response 88 Years of Influenza Pandemics in 15 Minutes Peter C. Kelly, M.D. Arizona Dept. of Health Services
Slide 2-

Bureau of Emergency Preparedness and Response Pandemic Influenza: history and background Peter C. Kelly, M.D., FACP Arizona Dept. of Health Services
Slide 3-

Bureau of Emergency Preparedness and Response Drivers for Pan Flu Preparedness WHO Influenza Preparedness SARS and Toronto Hurricane Katrina and New Orleans
Slide 4-

Bureau of Emergency Preparedness and Response It’s all about the virus
Slide 5-

Bureau of Emergency Preparedness and Response Influenza Virus RNA, 8 segments Unstable,mutates frequently Surface proteins Hemagglutinin Neuraminidase Niche in nature is birds
Slide 6-

Bureau of Emergency Preparedness and Response Drift and Shift Both refer to genetic changes Drift: Minor changes in H and N antigens; occur annually or every few years Shift: Major change (30% or more) in H and/or N antigens; “new” virus. Important for starting pandemics
Slide 7-

Bureau of Emergency Preparedness and Response Influenza is Global
Slide 8-

Bureau of Emergency Preparedness and Response Surface Glycoproteins Used to classify virus; H1, H2 etc Important in disease HA attaches virus to respiratory epithelial cells NA facilitates release of virus from infected cell Immunity/vaccines
Slide 9-

Bureau of Emergency Preparedness and Response Influenza Virus and Birds Migratory waterfowl Often not diseased Transmit to domestic birds and other animals 15 H types, 9 N types Only 3 H,2 N in humans Pathogenicity varies
Slide 10-

Bureau of Emergency Preparedness and Response How does the virus get to humans?
Slide 11-

Bureau of Emergency Preparedness and Response How does the virus get from person to person?
Slide 12-

Bureau of Emergency Preparedness and Response How does the virus cause disease? Attaches to respiratory epithelium Enters the cell and reproduces Causes cell death Primary target is bronchial tissue
Slide 13-

Bureau of Emergency Preparedness and Response Pandemics
Slide 14-

Bureau of Emergency Preparedness and Response Required for Influenza Pandemic “New” virus (antigenic shift) Susceptible population Transmitted from animals to humans Cause disease in humans Efficient person to person transmission
Slide 15-

Bureau of Emergency Preparedness and Response Influenza Pandemics Have occurred for centuries Occur 11 to 42 years apart Unpredictable but not random Attack rates of 10 to 40% Excess mortality But humanity survives
Slide 16-

Bureau of Emergency Preparedness and Response 20th Century
Slide 17-

Bureau of Emergency Preparedness and Response Current Model of Pandemics
Slide 18-

Bureau of Emergency Preparedness and Response 1918-19 Pandemic aka Spanish Flu H1N1 virus, Genetics: “avian like” First cases in USA Global spread ~1 yr Mortality 20-50 million USA 500,000
Slide 19-

Bureau of Emergency Preparedness and Response Impact High mortality Social disruption Burial Public services Events cancelled Spread along troop transport routes Poor public health response
Slide 20-

Bureau of Emergency Preparedness and Response Mortality and “Waves” Taubenberger, Morens. EID. 2006;12: 15-22.
Slide 21-

Bureau of Emergency Preparedness and Response “the Mother of All Pandemics” Taubenberger, Morens.EID.2006;12:15-22 H1N1 1918 virus is the ancestor of current influenza viruses Human and porcine lineage have some H1N1 genes H3N2 virus retains some H1N1 genes None of these as virulent as original
Slide 22-

Bureau of Emergency Preparedness and Response 20th Century
Slide 23-

Bureau of Emergency Preparedness and Response 1957-58 Influenza Pandemic Asian Influenza H2N2 virus: 3 new genes (H,N, PB1); 5 genes from 1918 H1N1 First cases in China Spread around world in 6 months 1st wave: Fall’57 school age 2nd wave: Jan’58 adults 80,000 deaths in USA Very young and elderly
Slide 24-

Bureau of Emergency Preparedness and Response 20th Century
Slide 25-

Bureau of Emergency Preparedness and Response 1968-69 Influenza Pandemic Hong Kong Influenza H3N2 Virus, 2 new genes(H, PB1), 5 retained from 1918. N2 from Asian Only 1 antigen shifted Population has some immunity to N2
Slide 26-

Bureau of Emergency Preparedness and Response H3N2 Influenza Lowest mortality of 20th cent. pandemics 34,000 deaths in USA U shaped mortality curve
Slide 27-

Bureau of Emergency Preparedness and Response Wave Phenomenon
Slide 28-

Bureau of Emergency Preparedness and Response Where are we now? H3N2 era. Seasonal influenza. Antigenic drift. Annual vaccine. Mortality ~36,000 SURPRISE 2003 H5 N1 avian virus Highly pathogenic in birds, especially chickens Almost world wide spread (asia,africa,and europe)
Slide 29-

Bureau of Emergency Preparedness and Response
Slide 30-

Bureau of Emergency Preparedness and Response
Slide 31-

Bureau of Emergency Preparedness and Response
Slide 32-

Bureau of Emergency Preparedness and Response Humans and H5N1 HPAI Few cases in close contact with chickens As of 7/14/06; 230 cases and 132 deaths No efficient human to human transmission
Slide 33-

Bureau of Emergency Preparedness and Response Required for Influenza Pandemic “New” virus (antigenic shift) Susceptible population Transmitted from animals to humans Cause disease in humans Efficient person to person transmission
Slide 34-

Bureau of Emergency Preparedness and Response WHO Alert
Slide 35-

Bureau of Emergency Preparedness and Response International Preparedness Control in birds Global Influenza Surveillance Vaccine development Antiviral drugs, oseltamivir National preparedness plans
Slide 36-

Bureau of Emergency Preparedness and Response Be an optimist! Power of scientific inquiry WHO global surveillance is good and getting better Communication and cooperation among nations is better since SARS Vaccine development and production methods are on a fast track
Slide 37-

Bureau of Emergency Preparedness and Response What about state and local PH?